製備新穎噻托品（ＴＩＯＴＲＯＰＩＵＭ）鹽類之方法，噻托品鹽類及其醫藥組合物农业专利-农业学术服务平台

发明人:: BANHOLZER, ROLF,罗夫　班侯勒,羅夫　班侯勒,PFRENGLE, WALDEMAR,沃德玛　普弗仁构,沃德瑪　普弗仁構,SIEGER, PETER,彼德　席格,罗夫班侯勒,羅夫班侯勒,沃德玛普弗仁构,沃德瑪普弗仁構,彼德席格

摘要：: Preparation of new tiotropilium salts (1) by subjecting a different tiotropilium salt (2) to anion exchange with an ion source in a solvent. Preparation of new tiotropilium salts of formula (1) by subjecting a different tiotropilium salt of formula (2) to anion exchange with an ion source (Kat-X) in a solvent. [Image] X : anion； Y : anion, different from X, i.e. halo, 1-10C alkyl-sulfonate or -sulfate, or 6-10C arylsulfonate； Kat : cation. An independent claim is also included for new compounds (1) and (2), except where Y/X = bromo, optionally as solvates or hydrates. ACTIVITY : Antiasthmatic. No details of tests for antiasthmatic activity are given. MECHANISM OF ACTION : Anticholinergic.本發明係關於一種製備新穎噻托品(tiotropium)鹽類之方法、該等新穎噻托品鹽類、含有該等鹽類之醫藥調配物及其用於製備供治療呼吸性疾病、尤其用於治療COPD(慢性阻塞性肺病)及哮喘之藥物的用途。