The present invention relates to a process for reducing the endotoxin levels in hCG, comprising steps of: a) subjecting hCG containing solution to atleast one or more precipitation steps including addition of organic or inorganic salt(s) and separating precipitate(s) by suitable means to obtain hCG solution with reduced endotoxin levels, b) subjecting the hCG solution with reduced endotoxin level to atleast one filtration step, preferably ultrafiltration step, c) subjecting ultrafiltered hCG solution to purification process for further reducing endotoxin levels and d) recovering hCG with reduced endotoxin levels of less than 0.03 EU/IU. The process of the present invention reduces the endotoxin levels to pharmacopeially acceptable levels in hCG for human consumption.
