PROBLEM TO BE SOLVED: To provide an orally disintegrating tablet which masks the bitter taste derived from butyl scopolamine bromide, and a method for producing the same.SOLUTION: The orally disintegrating tablet comprises granules that contain in the center thereof a raw drug-containing nucleus comprising butyl scopolamine bromide and water-insoluble particles, and in order from the raw drug-containing nucleus side are water-insoluble particles, an intermediate layer covering the raw drug-containing nucleus, talc, and a bitterness masking layer containing at least one type of water-insoluble polymer, and on the outside of the granules an excipient. The water insoluble particles contained in the raw drug-containing nucleus and intermediate layer comprise hydrous silicon dioxide. A production method therefor is also provided.SELECTED DRAWING: None【課題】ブチルスコポラミン臭化物に由来する苦味を遮蔽した口腔内崩壊錠及びその製造方法を提供する。【解決手段】ブチルスコポラミン臭化物及び水不溶性粒子を含む原薬含有核を中心に有し、原薬含有核側から順に、水不溶性粒子を含み、かつ、原薬含有核を被覆する中間層と、タルク及び少なくとも１種の水不溶性ポリマーを含む苦味マスキング層と、を有する細粒、並びに、細粒に対して外側の賦形成分を含む口腔内崩壊錠であって、原薬含有核及び中間層に含まれる水不溶性粒子が、含水二酸化ケイ素である、口腔内崩壊錠、及びその製造方法。【選択図】なし
