The present invention provides a novel pharmaceutical composition and method of making the same. The composition comprises an effective amount of an antiviral agent and a local anesthetic. The antiviral drug can be sorivudine. The local anesthetic can be lidocaine or its pharmaceutically acceptable salt.本發明提供新穎醫藥組合物及其製備方法。該組合物包含有效量之抗病毒劑及局部麻醉劑。該抗病毒藥物可為索立夫定(sorivudine)。該局部麻醉劑可為利多卡因(lidocaine)或其醫藥上可接受之鹽。