An apparatus or device and a method of using such device for lifting, separating, or removing a first material (e.g., targeted tissue) from a second material (e.g., tissue of a body lumen in a patient) is presented. The method generally comprises placing the distal end of the device to a location that is proximate to the first material； deploying a first anchor member (e.g., T-anchor) fastened to a suture strand into the first material； deploying a second anchor member (e.g., loop anchor) spaced away from the first anchor member, whereas the suture strand is slidably received by the second anchor member； applying tension to the suture strand； cutting the first material at a predetermined depth around the periphery of the first material； and separating or removing the first material along with the first anchor member. The tension applied to the suture strand maintains the first material in a raised position and/or allows the operator to manipulate the first material relative to the second material.
