Seth Ettenberg;Karen Cromie;Joost Kolkman;Kris Meerschaert;David Raymond Stover;Jingxin Zhang;Bruno Dombrecht;Jing Li
发明人:
Karen Cromie,Bruno Dombrecht,Seth Ettenberg,Joost Kolkman,Jing Li,Kris Meerschaert,David Raymond Stover,Jingxin Zhang
申请号：
US13024174
公开号：
US09120855B2
申请日:
2011.02.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
