Eszter NAGY,Adriana BADARAU,Harald ROUHA,Lukas STULIK,Irina MIRKINA,Michael B. BATTLES,Nels NIELSON
申请号：
US15567337
公开号：
US20180105584A1
申请日:
2016.04.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A monoclonal antibody that counteracts Staphylococcus aureus by specifically binding to wild-type immunoglobulin-binding proteins (IGBP) of S. aureus comprising a cross-specific CDR binding site recognizing at least three of the IGBP domains selected from the group consisting of Protein A (SpA) domains and immunoglobulin-binding protein (Sbi) domains SpA-A, SpA-B, SpA-C, SpA-D, SpA-E, Sbi-I, and Sbi-II, wherein the antibody has an affinity to bind SpA-E with a KD of less than 5×10−9M as determined by a standard optical interferometry method for a F(ab)2 fragment, and preferably binds to wt SpA equally or better compared to mutant SpA-KKAA that lacks binding to IgG Fc or VH3.
