CHEN CHRISTINE HIU-TUNG,CHIN NOEL CHIN,DIPIETRO LUCIAN V.,FAN JIANME,PALERMO MARK G,SHULTZ MICHAEL DAVID,TOURE BAKARY-BARRY
申请号：
NZ62042612
公开号：
NZ620426A
申请日:
2012.07.13
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions and combinations comprising a compound of formula (I) as well as the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. Examples of a compound of formula (I) are: 2-Chloro-6-{ 3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} benzonitrile 2-{ 3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} -3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one
