Hung, Jung-Tung,Lin, Kun-Hsien,Yu, Alice,Jan, Jia-Tsrong,Chang, Ya-Jen,Lin, Yi-Ling,Wong, Chi-Huey,Cheng, Y. S. Edmond
申请号：
AU2009268381
公开号：
AU2009268381B2
申请日:
2009.07.10
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present disclosure relates to synthetic alpha-galactosyl ceramide (α- GalCer) analogs, and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :； or a pharmaceutically acceptable salt thereof； forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte； and activating the lymphocyte to produce the cytokine response.
