As herein described the invention provides strengthens the solid oral transmucosal dosage form of relative quick acting that biologically active polypeptide is striden the through mucous membrane infiltration of oral mucosas tissue and effective treatment of this biologically active polypeptide is provided.The dosage form that is made according to the present invention can strengthen the polypeptide through mucous membrane and absorb and to enter the receiver and reach the treatment plasma concentration.The invention provides the solid dosage forms of the biologically active polypeptide oral transmucosal absorption that is used for, wherein said dosage form comprises pharmaceutical composition, and this pharmaceutical composition comprises: the therapeutic activity polypeptide Gallbladder salt And effervescent excipient component, it can comprise effervescent couple and the optional pH regulator material that comprises.The present invention includes the method that method that gives biologically active polypeptide and the through mucous membrane that strengthens biologically active polypeptide absorb.
