GRIBBLE, Gordon, W.,FU, Liangfeng,SPORN, Michael, B.,LIBY, Karen, T.
申请号：
USUS2013/039902
公开号：
WO2013/169740A3
申请日:
2013.05.07
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided. Furthermore, the present invention provides methods for producing a cell, such as a stem or progenitor cell, with induced gene expression by contacting a stem or progenitor cell with an effective amount of a synthetic triterpenoid to induce the expression of one or more of SOX9 (Sex determining region Y-box 9), COL2A1 (Type II Collagen (alphal )), TGF-βΙ, TGF-p2, TGF-33, BMP2, BMP4, BMPRII (Bone Morphogenic Protein Receptor II), SMAD (Small Mothers Against Decapentaplegic) 3, SMAD4, SMAD6, SMAD7, TIMP (Tissue Inhibitor of Metalloproteinase)-1 or TIMP-2 in the stem or progenitor cell, wherein the stem or progenitor cell is not a mesenchymal stem cell, periosteium cell or osteoprogenitor cell. In one embodiment, the stem or progenitor cell is multipotent.Linvention concerne des triterpénoïdes synthétiques et des procédés dutilisation de ceux-ci pour induire lexpression génique et la différenciation de cellules souches ou progénitrices.
