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RISPERIDONE-CONTAINING MICROCAPSULE, METHOD FOR MANUFACTURING SAME AND RELEASE CONTROL METHOD
专利权人:
发明人:
申请号:
EP16844355.4
公开号:
EP3348268A1
申请日:
2016.09.06
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention provides a microcapsule containing a biodegradable polymer and risperidone and having a sustained release property as well as a method of producing the same. Provided are a microcapsule containing a biodegradable polymer and risperidone, in which the biodegradable polymer contained in the microcapsule has a molecular weight corresponding to 85% or more of an initial molecular weight (Mw) of the biodegradable polymer a method of producing a microcapsule, comprising (A) a step of preparing a first phase by mixing a solution of a biodegradable polymer and a solution of risperidone which are prepared separately, (B) a step of, immediately after the preparation of the first phase, mixing the first phase with a second phase being an aqueous phase to prepare an emulsion, and (C) a step of subjecting the resulting emulsion to in-water drying and a method of controlling release of risperidone from a microcapsule containing a biodegradable polymer and risperidone, wherein the biodegradable polymer contained in the microcapsule has an Mw corresponding to 85% or more of an initial molecular weight (Mw) of the biodegradable polymer.
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中国工程科技知识中心
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