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PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF MACULAR DEGENERATION
专利权人:
КАТОЛИК ЮНИВЕРСИТИ ИНДАСТРИ АКАДЕМИК КООПЕРЕЙШН ФАУНДЕЙШН (KR);КОРЕЯ РИСЕЧ ИНСТИТЬЮТ ОФ КЕМИКАЛ ТЕКНОЛОДЖИ (KR)
发明人:
ЫЙ Кё-Ян (KR),Ю Сон-Ын (KR),КИМ Нак-Чон (KR),СОХ Чи-Хи (KR),ЧУ Чхюн-Ки (KR),ЧХВЕ Чон-Соп (KR),ЯН Чжэ-Сик (KR),ЛИ Кын-Хёг (KR),ЧО Юн-Сок (KR),ПАК Чин-Ха (KR),ЛИ Хе-Сон (KR)
申请号:
RU2013147449/04
公开号:
RU2013147449A
申请日:
2012.03.29
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A pharmaceutical composition for the prevention or treatment of macular degeneration, comprising a compound of Formula 1 or a pharmaceutically acceptable salt thereof as an active substance: <;Formula 1>; where R is H, CN, NO or NH, R is R, R and R are independent of each other and correspond to H, Cl, Branched, Br, F, C C straight or branched chain alkyl radical, OR, CF, OCF, NO or COR, R corresponds to a C C straight or branched chain alkyl radical, R corresponds to H or C C alkyl radical, and * corresponds to a chiral center. 2. The pharmaceutical composition for the prevention or treatment of macular degeneration according to claim 1, wherein the compound of Formula 1 is selected from the group consisting of: (2S, 3S, 4R) -6-nitro-4- [N- (4-chlorophenyl) -N- ( 1H-imidazol-2-ylmethyl) amino] -3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; (2S, 3R, 4S) -6-nitro-4- [ N- (4-chlorophenyl) -N- (1H-imidazol-2-ylmethyl) amino] -3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; (2R, 3R , 4S) -6-nitro-4- [N- (4-chlorophenyl) -N- (1H-imidazol-2-ylmethyl) amino] -3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro -2H-1-benzopyran; (2R, 3S, 4R) -6-nitro-4- [N- (4-chlorophenyl) -N- (1H-imidazol-2-ylmethyl) amines but] -3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; (2S, 3S, 4R) -6-nitro-4- [N- (4-trifluoromethylphenyl) - N- (1H-imidazol-2-ylmethyl) amino] -3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; (2S, 3S, 4R) -6-nitro 4- [N- (4-methoxyphenyl) -N- (1H-imidazol-2-ylmethyl) amino] -3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; ( 2S, 3S, 4R) -6-nitro-4- [N- (4-trifluoromethoxyphenyl) -N- (1H-imidazol-2-ylmethyl) amino] -3-hydroxy-2-methyl-2-dimethoxymethyl-3, 4-dihydro-2H-1-benzopyran; (2S, 3S, 4R) -6-nitro-4- [N- (4-bromophenyl) -N- (1H-imidazol-2-ylmethyl) amino] -3-hydroxy -2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyr n; (2S, 3S, 4R) -6-nitro-4- [N- (2,4-dime1. Фарма
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