ABSTRACT OF THE DISCLOSUREA controlled release sterile freeze-dried aripiprazole formulation is provided which is formed of aripiprazole of a desired mean particle size and a vehicle therefor, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks. A method for preparing the controlled release freeze-dried aripiprazole formulation, and a method for treating schizophrenia employing the above formulation are also provided.本發明提供一種控釋型無菌冷凍乾燥阿立哌唑(aripiprazole)調合物,其係由具有所需平均粒度之阿立哌唑與其適用媒劑所形成,該調合物在與水混成後以肌肉內注射投藥可以有至少約一週到高達約八週的時間能持續地釋出阿立哌唑。本發明還提供一種製備此等控釋型冷凍乾燥阿立哌唑調合物之方法以及使用如上調合物來治療精神分裂症之方法。
