Chemically and thermodynamically stable insulin analogues and improved methods for their production

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专利权人:

发明人:

Michael H. B. Stowell,Yanyu Peng,Mikhail Plam

申请号：

US14254867

公开号：

US09163073B2

申请日:

2014.04.16

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The subject matter of this invention is directed towards chemically and thermodynamically stable single-chain insulin (SCI) analogues that are resistant to deamidation and fibrillation. The invention further discloses improved methods for the recombinant expression, purification and refolding of SCI.

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