A resuscitation system includes first (12) and second (14) high-voltage defibrillation electrodes connected to a substrate (36). A CPR pad (e.g., a semi-rigid member) (18) interconnected with the substrate (36) is configured to be located over a region of a patient's body appropriate for chest compressions when the first and second electrodes (12, 14) are positioned over regions of the patient's body appropriate for defibrillation. A compression-sensing element such as an accelerometer, or a force-sensing element, is electrically connected to a resuscitation control system. A plurality of manually operable controls (20) are mechanically interconnected with the first and second electrodes (12, 14) and the CPR pad (18) and electrically connected to the resuscitation control system (26), which provides resuscitation prompts to a rescuer based on use of the manually operatable control (20) by the rescuer. A second control (30) is positioned on the resuscitation control system (26) that can be operated by a rescuer to indicate that the patient is ready for application of a defibrillation shock. A pulse detection system (52) detects whether the patient has a pulse when the substrate is in contact with the patient.
