Described here are systems and methods for obtaining measurements of both tissue perfusion and permeability with a magnetic resonance imaging (“MRI”) system after the administration of a single dose of contrast agent. To this end, the MRI system is directed to acquire T2*-weighted data, during which the acquired signal values are monitored for a trigger event. When the trigger event occurs, the MRI system is directed to switch from acquiring the T2*-weighted data to acquiring T1-weighted data. The systems and methods of the present invention can thus be used for a fully automated, single acquisition of perfusion and permeability measurements using only a single dose of contrast agent.
