The present Invention relates to Derivatives of pyrazole amide compounds of formula (i), or pharmaceutically acceptable salts thereof, which have Inhibitory activity of pyruvate dehydrogenase Kinase (pdhk) and are used as a prophylactic or therapeutic agents in the treatment of di ABETES Syndrome, insulin resistance, metabolic syndrome.Hyperlactataemia, hyperglycemia, diabetic complications, cardiomyopathy, Heart Failure, Myocardial Ischemia, myocardial infarction, among others. Also included are Pharmaceutical compositions containing themLa presente invencion esta referida a compuestos derivados de pirazol-amida de Formula l, o sus sales farmaceuticamente aceptables, los cuales tienen actividad inhibidora de la piruvato deshidrogenasa cinasa (PDHK) y son empleados como agentes profilacticos o terapeuticos en el tratamiento de la diabetes, sindrome de resistencia a la insulina, sindrome metabolico. hiperglucemia, hiperlactacidemia, complicaciones diabeticas, insuficiencia cardiaca, cardiomiopatia, isquemia miocardica, infarto de miocardio, entre otras. Tambien se incluyen composiciones farmaceuticas que los contienen
