A medical device material impregnated with a combination of antimicrobialagents, the combination of antimicrobial agents comprising a firstantimicrobial agent, the first antimicrobial agent being triclosan and atleast a second antimicrobial agent, wherein the combination of antimicrobialagents provides the device material with antimicrobial activity and inhibitionof resistant microbial mutations for of the order of, or greater than, 80 days.