Cytochrome P450 suicide gene system

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专利权人:

发明人:

申请号：

EP12170232.8

公开号：

EP2669378A1

申请日:

2012.05.31

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The invention relates to a modified human CYP4B1 protein and a nucleic acid encoding for the modified human CYP4B1 protein. The invention further relates to an expression vector comprising a nucleic acid encoding for a modified human CYP4B1 protein, as well as to a cell comprising a modified CYP4B1 protein. In addition, the invention relates to a modified human CYP4B1 protein for use in treating transplantation induced graft-versus-host-disease (GvHD), and to 4-ipomeanol (4-IPO) for use in killing a cell.

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