DUTZAR, BENJAMIN H.,KOVACEVICH, BRIAN ROBERT,MITCHELL, DANIELLE MARIE,OJALA, ETHAN WAYNE,FAN, PEI,SMITH, JEFFREY T.L.,MCNEILL, PATRICIA DIANNE,BILLGREN, JENS,STEWART, ERICA ANN,AKATSUKA, CORINNE C.,CH
申请号：
CA2821515
公开号：
CA2821515A1
申请日:
2011.12.01
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention is directed to antibodies and fragments thereof having binding specificity for NGF, especially those that inhibit the interaction of NGF with TrkA and/or p75 or p75 and/or TrkA. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
