A production method for a granular composition in which the dissolution property of 2-{4- [N-(5,6-diphenylpyradin-2-yl)-N-isopropylamino]butylo xy}-N-(methylsulfonyl)acetamide is improved is provided.A production method for a granular composition includes a compression molding step of compression molding a mixture obtained by mixing 2-{4-[N-(5,6-diphenylpyradin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide and at least one or more excipients selected from the group consisting of a sugar alcohol, a starch, and a saccharide, thereby obtaining a compression molded material.本發明提供一種粒狀組合物之製造方法，該製造方法使2-{4-[N-(5,6-二苯基吡?-2-基)-N-異丙基胺基]丁氧基}-N-(甲磺醯基)乙醯胺之溶出性提昇。粒狀組合物之製造方法包含壓縮成形步驟，該壓縮成形步驟係將混合有2-{4-[N-(5,6-二苯基吡?-2-基)-N-異丙基胺基]丁氧基}-N-(甲磺醯基)乙醯胺與選自由糖醇類、澱粉類、及糖類所組成之群中之至少1種以上之賦形劑之混合物壓縮成形而獲得壓縮成形物。
