Sophie Hallakou-Bozec;Daniel Cravo;Didier Mesangeau;Samer Elbawab
发明人:
Daniel Cravo,Sophie Hallakou-Bozec,Didier Mesangeau,Samer Elbawab
申请号：
US12998848
公开号：
US09035048B2
申请日:
2009.12.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to compounds of formula (I) wherein the radicals R1 to R6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with the activity of AMP-activated protein kinase (AMPK). Another object of the invention concerns the use of said compounds for enhancing glucose homeostasis, improving podocytopathy and/or decreasing the production of reactive oxygen species (ROS). The invention also relates to a method for in-vitro diagnosing diabetic nephropathy and a method for screening compounds that reduce podocytopathy, in each case by applying synaptopodin as biomarker.
