The present invention relates to compounds and methods for inhibition of binding of ICAM-4 to platelet integrin αIIbβ3.The present invention also relates to a screening method and to a kit to detect or monitor in vitro the effect of a substance, drug or pharmaceutical agent on the ICAM-4/αIIbβ3 interaction in a biological sample, while simulating blood flow conditions existing in vivo.It concerns in particular an anti-ICAM-4 antibody or a fragment thereof capable of blocking ICAM-4 binding to platelet integrin αIIbβ3, or an ICAM-4 mimetic peptide blocking ICAM-4 binding to platelet integrin αIIbβ3, or an anti-CD61 antibody or a fragment thereof capable of blocking ICAM-4 binding to platelet integrin αIIbβ3, for use in the treatment of a thrombotic disease, and for the preparation of pharmaceutical compositions for such treatment.
