PROBLEM TO BE SOLVED: To provide a new composition having IL-1RA production promoting action.SOLUTION: The present invention provides a composition for promoting IL-1RA production by skin cells, the composition containing yeast extract and vitamin B2.SELECTED DRAWING: Figure 2COPYRIGHT: (C)2018,JPO&INPIT【課題】新たなIL-1RA産生促作用を有する組成物を提供することを課題とする。【解決手段】酵母抽出液とビタミンB2を含有する皮膚細胞のIL-1RA産生促進組成物。【選択図】図2