compound, pharmaceutical composition, method of treatment, method of treating a disease or condition caused, exacerbated or resulting from an excess of platelets or unwanted activation of platelets in a patient, method for reducing a patient's circulating platelet count and use
ABBOTT LABORATORIES;THE WALTER AN ELIZA HALL INSTITUTE OF MEDICAL RESEARCH;GENENTECH, INC
发明人:
ANDREW J. SOUÉRS,ANDREW M. PETROS,BRAD EDMUND SLEEBS,BRIAN JONH SMITH,CARL STEVEN RYE,CHINH THIEN BUI,CHUDI NDUBAKU,DANETTE A. DUDLEY,GEORGE NIKOLAKOPOULOS,GUILLAUME LAURENT LESSENE,JONATHAN BAYLDON B
申请号：
BRPI0918337
公开号：
BRPI0918337A2
申请日:
2009.12.17
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
