Robert H. MACH,Sean REILLY,Mehran MAKVANDI,Kuiying XU,Daniel A. PRYMA,Roger A. GREENBERG
申请号:
US16616049
公开号:
US20200109156A1
申请日:
2018.05.24
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present disclosure relates to compounds of Formula I and II, wherein R1-R20 and FL are defined herein. Also provided are methods of targeting alpha-radiation to poly(ADP-ribose)polymerase 1 (PARP-1) enzyme expression, reducing proliferation of cancer cells, reducing proliferation of cancer cells, detecting intact and enzymatically active poly(ADP-ribose)polymerase 1 (PARP-1) enzyme expression, detecting PARP-1 enzyme expression in a subjects tissue sample, monitoring cancer treatment in a subject, or detecting a PARP-1 receptive cancer in a subject.