NICOLAU, YVES CLAUDE,GREFERATH, RUTH,HICKMAN, DAVID
申请号：
CA2556479
公开号：
CA2556479C
申请日:
2005.02.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention comprises novel compositions and methods for elicitinghigh immune responses, of great specificity yielding conformationallysensitive antibodies. These antibodies recognize specific epitopes on a widevariety of antigens including but not limited to, amyloid protein, prionprotein, P170 glycoprotein. The novel compositions of the invention comprisesupramolecular antigenic constructs generally comprising a peptide sequence,covalently attached to pegylated lysine resulting in modified and enhancedpeptide presentation. The unique modification methodology of the presentinvention is applicable to a variety of peptides and can ultimately beemployed in therapeutic formulations and vaccines for diseases and disorderssuch as Alzheimer's disease.
