MODIFIED OLIGO-NUCLEIC ACID MOLECULE, PREPARATION METHOD AND USES THEREOF

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专利权人:

发明人:

申请号：

EP10757994.8

公开号：

EP2415869A1

申请日:

2010.03.30

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention relates to a modified oligonucleotide, its preparation and application. The invention eables stabilizing the oligonucleotide by introducing a relatively small amount of modified nucleotide at specific UA/UA and/or CA/UG and/or UG/CA site of the oligonucleotide, therefore to decrease the modification-related cytotoxicity and compromising effects on the biological activity.

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