The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.La présente invention concerne de nouveaux aminotétrahydropyranes substitués de formule structurelle I qui sont des inhibiteurs de lenzyme dipeptidyl peptidase-IV et qui sont utiles pour le traitement ou la prévention de troubles dans lesquels lenzyme dipeptidyl peptidase-IV est impliquée, tels que le diabète et en particulier le diabète de type 2. Linvention concerne également des compositions pharmaceutiques comprenant ces composés et lutilisation de ces composés et compositions pour prévenir ou traiter des maladies dans lesquelles lenzyme dipeptidyl peptidase-IV est impliquée.
