Pharmaceutical compositions and methods for treating diseases associated with angiogenesis and inflammation. The invention relates to a pharmaceutical composition that includes a therapeutically effective amount of sCD26 and/or a biologically active derivative thereof and a pharmaceutically acceptable carrier. The composition may further include a therapeutically effective amount of sFlt-1 and/or a biologically active derivative thereof. Additionally, the invention relates to methods for treating a disease associated with and/or progresses by an inflammatory cytokine-associated inflammation and/or VEGF-associated angiogenesis.本發明係一種用於治療與血管新生和發炎有關之疾病的醫藥組合物及方法。該醫藥組合物用於哺乳動物以治療一種與VEGF相關的血管新生及/或發炎性細胞激素相關的發炎有關的疾病。該組合物含有：(a)具有治療效果之劑量的可溶性CD26；(b)具有治療效果之劑量的可溶性Flt-1；(c)以及一種醫藥上可以接受的載體。該方法包括將此醫藥組合物用於哺乳動物而使其受益的步驟。
