Kenneth R. Chien,Ibrahim J. Domian,Murali Chiravuri,Peter Van Der Meer,Kevin Kit Parker,Adam W. Feinberg
申请号：
US13121279
公开号：
US20120027807A1
申请日:
2009.10.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention generally relates to a population of committed ventricular progenitor (CVP) cells and their use to generate a tissue engineered myocardium, in particular two dimensional tissue engineered myocardium which is comparable to functional ventricular heart muscle. One embodiment of present invention provides a composition and methods for the production of a tissue engineered myocardium which has functional properties of cardiac muscle, such as contractibility (e.g. contraction force) and numerous properties of mature fully functional ventricular heart muscle tissue. In particular, in one embodiment, a composition comprising the tissue engineered myocardium comprises committed ventricular progenitor (CVP) cells seeded on a free-standing biopolymer structure to form functional ventricular myocardium tissue.
