Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a &bgr;-cyclodextrin, e.g., a sulfo butyl ether &bgr;-cyclodextrin, e.g., a &bgr;-cyclodextrin, e.g., a sulfo butyl ether &bgr;-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.