Jun Li,Suwan Sun,Jiang Li,Jing Jiang,Ningshao Xia,Tong Cheng,Lunzhi Yuan
申请号：
US16355723
公开号：
US20190209712A1
申请日:
2019.03.16
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A humanized murine model of chronic hepatitis B constructed using human stem cells, obtained by obtaining the human stem cells； transplanting the human stem cells into a murine with liver damage to achieve presence of 1×104-8 of the human stem cells in the murine in vivo； etc. The humanized murine model may be used for the study of drug resistance to the antiviral drugs, the study of the pathogenesis of chronic hepatitis B, etc. In addition to the study of the mechanism of hepatitis B viral infection, the humanized murine model may also be used for research in treatment.
