Hayley Binch;Paul S. Charifson;Julian M.C. Golec;Jean-Damien Charrier
发明人:
Julian M.C. Golec,Paul S. Charifson,Jean-Damien Charrier,Hayley Binch
申请号：
US13309117
公开号：
US20120077830A1
申请日:
2011.12.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention provides novel compounds, and pharmaceutically acceptable derivatives thereof, that are useful as caspase inhibitors. These compounds have the general formula I:where R1, R2, and R3 are as described herein, Ring A contains zero to two double bonds, each X is independently selected from nitrogen or carbon, at least one X in Ring A is a nitrogen, Ring A is optionally substituted as described, and may be fused to a saturated or unsaturated five to seven membered ring containing zero to three heteroatoms, and provided that when X3 is a carbon, a substituent on X3 is attached by an atom other than nitrogen.
