INDUSTRY ACADEMIC COOPERATION FOUNDATION; HALLYM UNIVERSITY
发明人:
CHOI, SU YOUNG,최수영,UM, WON SIK,음원식,KIM, DAE WON,김대원,PARK, JIN SEO,박진서,KIM, DUK SOO,김덕수
申请号：
KR1020110101576
公开号：
KR1020130037271A
申请日:
2011.10.06
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A cell permeable DJ-1 fusion protein is provided to protect cells from apoptosis due to reactive oxygen species in astrocytes and to be used as an agent for preventing and treating brain ischemia.CONSTITUTION: A cell permeable DJ-1 fusion protein contains HIV Tat protein transport domain conjugated at C-terminal and/or N-terminal of CJ-1 protein. The fusion protein has an amino acid sequence of sequence number 5, 7, or 9.COPYRIGHT KIPO 2013본 발명은 세포 투과성 DJ-1 융합단백질에 관한 것으로서, 좀더 구체적으로는 DJ-1 융합단백질이 세포 내로 효율적으로 투과하여 인비트로와 인비보에서 세포사멸을 보호하고, 뇌허혈에 대한 치료제로서의 효능을 밝혔다.
