Marc A. Gavin,Gunasekaran Kannan,Li Li,Joshua T. Pearson,Margaret Karow
申请号：
US15408281
公开号：
US09932380B2
申请日:
2017.01.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
