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RHENIUM COMPLEXES AND THEIR PHARMACEUTICAL USE
专利权人:
Philippe Collery
发明人:
Philippe Collery,Jean DAngelo,Georges Morgant
申请号:
US13701191
公开号:
US20130158109A1
申请日:
2011.06.01
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention is directed to a rhenium complex of general Formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein X is Se Y is NH, O or S or is a methylene group Z is halogen m=0, 1, or 2 and p=0, 1, or 2, provided that m and p are both different from zero when Y is NH, O or S n=3 R′ is a phenyl group or a group of general Formula —(CH2)q—COOH wherein q=1 or 2, a pharmaceutical composition comprising a therapeutically effective amount of at least one of such rhenium complex where X is additionally S or Te, a method for preparing said rhenium complex and a method for treating a proliferative growth related-disorder using a therapeutically effective amount of at least one of said rhenium complex where X is additionally S or Te. Also claimed is the use of compounds of formula (II) in the preparation of compounds of formula (I).
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