Leonard M. Neckers,Carole A.C. Sourbier,W. Marston Linehan,Jane B. Neckers,Min-Jung Lee,Bradley T. Scroggins,John A. Beutler
申请号：
US14370140
公开号：
US20140350093A1
申请日:
2013.01.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R1-R6 are described herein. Examples of diseases or conditions associated with insulin resistance include diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality in a female, and growth abnormality.
