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processos melhorados para produção de hidrazidas
专利权人:
Wyeth LLC
发明人:
Chiarello, George,Sahli, Ayman
申请号:
ES12159159
公开号:
ES2686019T3
申请日:
2008.05.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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