NOVEL SALT OF FUSED PYRIMIDINE COMPOUND AND CRYSTAL THEREOF

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专利权人:

Taiho Pharmaceutical Co.; Ltd.

发明人:

Oshiumi, Hiromi

申请号：

AU2016213031

公开号：

AU2016213031A2

申请日:

2016.01.29

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Provided is a salt that has high selectivity for BTK and that is useful as an active pharmaceutical ingredient. It was discovered that a fumarate of (R)-1-(1-acryloylpiperidine-3-yl)-4-amino-N-(benzo[d]oxazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide (compound A) represented by formula (1) does not have the qualities of a channel hydrate, and exhibits excellent stability and absorption properties in comparison to compound A and other salts thereof.

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