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Perivascular mesenchymal precursor cell induced blood vessel formation
专利权人:
Mesoblast; Inc.
发明人:
Gronthos, Stan,Zannettino, Andrew
申请号:
AU2014203718
公开号:
AU2014203718A1
申请日:
2014.07.08
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
#$%^&*AU2014203718A120140724.pdf#####ABSTRACT Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilising a perivascular marker. A new mesenchymal precursor cell phenotype is described characterised by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as STRO-1 and CD146/MUC18. The perivascular mesenchymal precursor cell is shown to induce neovascularisation and improvement in cardiac function. Suitable administration of preparations of the mesenchymal precursor cells are useful for treatment of cardiovascular diseases, cerebrovascular diseases and peripheral vascular diseases.
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