LEE, Chun Ho,LEE, Seung Chul,LEE, Yeon Im,EOM, Deok Ki,HAN, Mi Ryeong,KOH, Eun Ji
申请号：
PH12017501755
公开号：
PH12017501755A1
申请日:
2017.09.25
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically cceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori. Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.
