A lyophilization system (200) to lyophilize the bulk product by removing a liquid, comprising: a lyophilization chamber (210) to contain the product during the lyophilization process； at least one bulk product spray nozzle (212) connected to a source (211) of the bulk product, the at least one bulk product spray nozzle being directed to an interior of the freeze-drying chamber to spray the product to bulk in the freeze-drying chamber； at least one spray nozzle of the freezing agent (214) connected to a source (213) of a freezing agent, the at least one spray nozzle of the freezing agent being directed into the freeze drying chamber to spray the blowing agent freezing in the freeze-drying chamber, the at least one spray nozzle of the bulk product (212) and the at least one spray nozzle of the freezing agent (214) additionally directed to respective sprays that are mixed inside the chamber lyophilization (210) to create a spray frozen product； a heater (230, 271) to heat at least the bottom walls of the lyophilization chamber； a condensing chamber (250) in communication with the lyophilization chamber and comprising surfaces for condensing a vapor of the exhaust gas received from the lyophilization chamber； a vacuum pump (260) in communication with the condensation chamber； and 20 a stirring mechanism (235； 335,339) in a lower portion of the lyophilization chamber (210) to stir the frozen product by accumulation of spray in the lower portion of the chamber to move particles of the product into contact with the walls of the lyophilization chamber； The lyophilization system is characterized in that it further comprises: a controller comprising memory that stores a program that, when executed by the controller, causes the lyophilization system to carry out: an aseptic spray freeze cycle in which bulk product is sprayed from the at least one bulk product nozzle into the freeze-drying chamber and a freezing agent is sprayed from the at least one freezing agent spray nozzle
