A METHOD FOR TREATING ACUTE ISCHEMIC STROKE IN A HUMAN COMPRISES ADMINISTERING TENECTEPLASE TO THE HUMAN IN A TOTAL DOSE OF ABOUT 0.05 TO 0.5 MG/KG, GIVEN AS (A) AN INITIAL BOLUS DOSE OF ABOUT 0.015 TO 0.15 MG/KG, FOLLOWED BY INFUSION OF AN AMOUNT EQUALING THE TOTAL DOSE MINUS THE INITIAL DOSE OVER A PERIOD OF ABOUT 50-90 MINUTES, OR (B) A BOLUS. ALSO DESCRIBED ARE KITS FOR CARRYING OUT THIS METHOD. FIG. 1