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New azaquinine derivatives
专利权人:
BAYER ANIMAL HEALTH GMBH
发明人:
GRIEBENOW, Nils,ZHUANG, Wei,KOHLER, Adeline,KULKE, Daniel,BOHM, Claudia,BORNGEN, Kirsten,ILG, Thomas,SCHWARZ, Hans-Georg,HALLENBACH, Werner,GORGENS, Ulrich,HUBSCH, Walter,ALIG, Bernd,HEISLER, Iring,JA
申请号:
PE2019002610
公开号:
PE20200608A1
申请日:
2018.06.22
申请国别(地区):
PE
年份:
2020
代理人:
摘要:
Refers to azakinone compounds extracted from the general formula (I),A is A1 or A2; or 0, 1, 2, 3 or 4; R is hydrogen, halides, etc.; X and y are selected independently of cr7r8, O, s, and n-r9 groups; or together they form a member of a selected ring in the group consisting of - C (o) - O,-C(O)-Nr9--Among other things, t is selected from T1-T6; R1 is hydrogen, cyanide, CHO, etc.; R10 is hydrogen-oh, tar-c1-c4 and alcoy-c1-c4; R11 is hydrogen, tar-c1-c4 and alcox-c1-c4; or R10 and R11 together with carbon form a ring of 3 to 6 members. The most popular compounds are n - [(4S) - 3,4-dihydro-2h-1-benzopiran-4-il] - 4 - (morfolin-4-il) - 8 - (2,3,5-trifluorophenyl) - 1,7-naftiridina-3-carboxamida; N - [(4S) - 3,4-dihydrow-2h-cronen-4-il] - 4 - (morfolin-4-il) - 8 - (2,3,5-trifluorophenyl) - trifluoroamide-3, and other compounds. These compounds effectively interact with slo-1 of nematodes, thus achieving their paralysis and inhibition,It is very useful in the treatment or prevention of intestinal and extraintestinal helminth infections He also mentioned a pharmacology composer who included the compound.Se refiere a compuestos derivados de azaquinolona de la formula general (I), donde A es A1 o A2; o es 0, 1, 2, 3 o 4; R es hidrogeno, halogeno, entre otros; X e Y se seleccionan independientemente del grupo que consiste en CR7R8, O, S y N-R9; o forman conjuntamente un miembro del anillo seleccionado del grupo que consiste en -C(O)-O-, -C(O)-NR9-, entre otros; T se selecciona de T1- T6; R1 es hidrogeno, ciano, -CHO, entre otros; R10 es hidrogeno, -OH, alquilo-C1-C4 y alcoxi-C1-C4; R11 es hidrogeno, alquilo-C1-C4 y alcoxi-C1-C4; o R10 y R11 forman, junto con el carbono al que estan unidos, un anillo de 3 a 6 miembros. Son compuestos preferidos: N-[(4S)-3,4-dihidro-2H-1-benzopiran-4-il]-4-(morfolin-4-il)-8-(2,3,5-trifluorofenil)-1,7-naftiridina-3-carboxamida; N-[(4S)-3,4-dihidro-2H-cromen-4-il]-4-(morfolin-4-il)-8-(2,3,5-trifluorofenil)-1,7-naftiridina-3-carboxamida, entre
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