This promotion provides various methods, including managing individuals to reduce or inhibit tigit activities and / or performance, such as an anti tigit antibody, including at least one HVR containing a series of amino acids, with numbers of: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 4, In addition, there are also anti-cancer agents, such as rental agents, anti hormone agents, aromatic inhibitors, etc. Toolkits including anticancer agents, agents that reduce or inhibit tigit activity and / or performance, or both, are also provided, along with guidelines for their use.La presente divulgacion provee metodos que comprenden la administracion al individuo de un agente que reduce o inhibe la actividad y/o la expresion de TIGIT tal como un anticuerpo anti-TIGIT que comprende al menos una HVR con una secuencia de aminoacidos SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, entre otros y un agente contra el cancer tal como un agente alquilante, un agente antihormonal, un inhibidor de aromatasa, entre otros. Tambien se proveen kits que comprenden un agente contra el cancer, un agente que reduce o inhibe la actividad y/o la expresion de TIGIT, o ambas, asi como instrucciones para su uso
