AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;TESSA THERAPEUTICS PTE. LTD.
发明人:
Jieming ZENG,Shu WANG,Andrew KHOO
申请号：
US15563542
公开号：
US20180078627A1
申请日:
2016.03.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
There is provided a method of loading antigen in a dendritic cell for antigen presentation, the method comprising: modifying a pluripotent stem cell with a nucleic acid molecule encoding an antigen or one or more immunogenic epitopes thereof； inducing the pluripotent stem cell to differentiate into a dendritic cell that expresses and presents the antigen or the one or more immunogenic epitopes thereof. Dendritic cells, vaccines and methods of using the dendritic cells and vaccines are also provided.
