Device (1) for opening/closing an autoclave (100) having an opening (101) for inputting/outputting one or more products to be sterilized, said device (1) comprising a frame (2) arranged at the edges (101a, 101b, 101c, 101d) of said opening (101), and at least one door (3) combinable with said frame (2) by sliding between a closed position and an open position, characterized in that said frame (2) is of framing type and comprises at least one first part (2a) arranged on a first edge (101a) of said opening (101) and provided with at least one linear guide (10) operatively facing the outer side of said opening, and in that said door (3) comprises a central body (20) and at least one first portion (21) provided with at least one first linear profile (22) operatively facing the inside of said opening and sliding along said guide of said at least one first part, said at least one first portion being distinct from said central body and being constrained along at least one first end (20a) of said central body (20).