In alternative embodiments, provided are pharmaceutical compositions and methods for treatment, amelioration and prevention of infection-associated blood vessel diseases, and also for the treatment, amelioration and prevention of non-vessel diseases affected by infective agents which can be treated by these compositions. In alternative embodiments, one common pathogen targeted by compositions and methods as provided herein is Chlamydia and Chlamydophila species, including pneumoniae, trachomatis and psittaci species which infect humans, including Chlamydophila pneumoniae which also infects humans. In alternative embodiments, pathogens targeted and infections (diseases) treated, ameliorated, or prevented by compositions and methods as provided herein include Mycoplasma, Listeria, Leptospirosis, Q fever or Coxiella burnetii infection, Lyme disease or Lyme borreliosis or any Borrelia infection, and Bartonella or of the family Bartonellaceae, including cat scratch disease. The compositions comprise at least three different antibiotic agents selected with compositions comprising a rifamycin (such as rifabutin), a macrolide (such as clarithromycin or azithromycin), and a tetracycline (such as doxycycline) or a nitrofuran (such as furazolidone) being preferred.L'invention concerne, selon divers modes de réalisation, des compositions pharmaceutiques et des méthodes pour le traitement, l'amélioration et la prévention de maladies des vaisseaux sanguins associées à une infection et, également, pour le traitement, l'amélioration et la prévention de maladies non vasculaires dues à des agents infectieux et qui peuvent être traitées par ces compositions. Dans d'autres modes de réalisation, les agents pathogènes communs ciblés par les compositions et les méthodes selon l'invention appartiennent aux genres Chlamydia et Chlamydophila, y compris les espèces pneumoniae, trachomatis et psittaci qui infectent l'être humain, et y compris Chlamydophila pneumoniae qui infecte également l'êt
